StressCovidV1, France, Analysis, bibRecord, 000080

Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity

Identifieur interne : 000080 ( France/Analysis ); précédent : 000079; suivant : 000081

Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity

Auteurs : C. Morel [France] ; S. Fernandez [France] ; F. Pantouli [Royaume-Uni] ; F. Meye [France] ; F. Marti [France] ; S. Tolu [France] ; S. Parnaudeau [France] ; H. Marie [France] ; F. Tronche [France] ; U. Maskos [France] ; M. Moretti [Italie] ; C. Gotti [Italie] ; M-H Han [États-Unis] ; A. Bailey [Royaume-Uni] ; M. Mameli [France] ; J. Barik [France] ; P. Faure [France]

Source :

Molecular Psychiatry [ 1359-4184 ] ; 2018.

RBID : Hal:hal-02182455

Abstract

Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.

Url:

https://hal.sorbonne-universite.fr/hal-02182455

DOI: 10.1038/mp.2017.145

Affiliations:

France, Italie, Royaume-Uni, États-Unis

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 000940
to stream Main, to step Exploration: 000940
to stream France, to step Extraction: 000080

Links to Exploration step

Hal:hal-02182455

Le document en format XML

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<idno type="DOI">10.1038/mp.2017.145</idno>
<series><title level="j">Molecular Psychiatry</title>
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<front><div type="abstract" xml:lang="en">              <p>Epidemiological studies report strong association between mood disorders and tobacco addiction. This high comorbidity requires adequate treatment but the underlying mechanisms are unknown. We demonstrate that nicotine exposure, independent of drug withdrawal effects, increases stress sensitivity, a major risk factor in mood disorders. Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (DA) system. This interplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental area (VTA) DA neurons' activity and stress-related behaviors, such as social aversion. Blocking β2 or α7 nicotinic acetylcholine receptors (nAChRs) prevents, respectively, the development and the expression of social stress-induced neuroadaptations; conversely, facilitating α7 nAChRs activation specifically in the VTA promotes stress-induced cellular and behavioral maladaptations. Our work unravels a complex nicotine-stress bidirectional interplay and identifies α7 nAChRs as a promising therapeutic target for stress-related psychiatric disorders.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Morel, C" sort="Morel, C" uniqKey="Morel C" first="C." last="Morel">C. Morel</name>
</noRegion>
<name sortKey="Barik, J" sort="Barik, J" uniqKey="Barik J" first="J" last="Barik">J. Barik</name>
<name sortKey="Faure, P" sort="Faure, P" uniqKey="Faure P" first="P." last="Faure">P. Faure</name>
<name sortKey="Fernandez, S" sort="Fernandez, S" uniqKey="Fernandez S" first="S" last="Fernandez">S. Fernandez</name>
<name sortKey="Mameli, M" sort="Mameli, M" uniqKey="Mameli M" first="M." last="Mameli">M. Mameli</name>
<name sortKey="Marie, H" sort="Marie, H" uniqKey="Marie H" first="H" last="Marie">H. Marie</name>
<name sortKey="Marti, F" sort="Marti, F" uniqKey="Marti F" first="F." last="Marti">F. Marti</name>
<name sortKey="Maskos, U" sort="Maskos, U" uniqKey="Maskos U" first="U." last="Maskos">U. Maskos</name>
<name sortKey="Meye, F" sort="Meye, F" uniqKey="Meye F" first="F." last="Meye">F. Meye</name>
<name sortKey="Parnaudeau, S" sort="Parnaudeau, S" uniqKey="Parnaudeau S" first="S." last="Parnaudeau">S. Parnaudeau</name>
<name sortKey="Tolu, S" sort="Tolu, S" uniqKey="Tolu S" first="S." last="Tolu">S. Tolu</name>
<name sortKey="Tronche, F" sort="Tronche, F" uniqKey="Tronche F" first="F." last="Tronche">F. Tronche</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Pantouli, F" sort="Pantouli, F" uniqKey="Pantouli F" first="F" last="Pantouli">F. Pantouli</name>
</noRegion>
<name sortKey="Bailey, A" sort="Bailey, A" uniqKey="Bailey A" first="A" last="Bailey">A. Bailey</name>
</country>
<country name="Italie"><noRegion><name sortKey="Moretti, M" sort="Moretti, M" uniqKey="Moretti M" first="M" last="Moretti">M. Moretti</name>
</noRegion>
<name sortKey="Gotti, C" sort="Gotti, C" uniqKey="Gotti C" first="C." last="Gotti">C. Gotti</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Han, M H" sort="Han, M H" uniqKey="Han M" first="M-H" last="Han">M-H Han</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity

Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity

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